The Central Radio, Film and Television Station has continuously criticized Canada for being the vanguard of "kidnapping"

  CCTV NewsChina Central Radio and Television’s "International Sharp Review" published two consecutive commentaries this morning on Meng Wanzhou’s detention, directly pointing out that Canada acts as a "human rights defender" of other countries and acts as a vanguard in this "****". Ask Canada’s judiciary and government to stop at the precipice in this "****" and not kidnap themselves.

  The full text of the two comments is as follows:

  "International Sharp Review: Whose" Human Rights Defender "Canada Is Being" points out:

  中国著名民营企业华为CFO孟晚舟女士本月1日在加拿大转机时被加拿大应美方要求逮捕。当地时间星期五(7日),针对孟晚舟被拘押一事的保释听证会在温哥华法庭举行,长达五小时的听证会没有做出裁决,被推迟到下周一(10日)继续举行。

  孟女士被捕并被拘押,在国际社会掀起一场龙卷风,引发了华为公司、中国民众和中国政府的震惊和愤慨,也引起国际舆论的哗然和指责。这场龙卷风带来的飞沙走石让这么几个真相更加清晰地暴露在世界面前。它们会让加拿大付出意想不到的沉重代价。

  首先,一向以法律完备、公平正义自居的美国、加拿大将因此事件使其司法公正变成“皇帝的新衣”,其霸权和无赖的内核赤裸裸地暴露在世人面前。

  早在6年前,美国国会报告称华为的设备会对美构成国家安全威胁,并禁止华为在美销售电信设备。其后,华为曾打算重返美国市场,但终因美国政府阻挠而告吹。不论从哪个角度讲,华为都谈不上违反美国法律,对华为高管的调查和指控纯属子虚乌有。

  对于加拿大逮捕孟女士的理由,据媒体报道,纽约东区检方申请加拿大逮捕孟晚舟的理由,是其涉嫌违反了针对伊朗的制裁禁令。华为第一时间发表声明称,华为遵守业务所在国的所有适用法律法规,包括联合国、美国和欧盟适用的出口管制和制裁法律法规。而美国对伊朗进行制裁本身就违反国际法。今年10月3日,联合国国际法院裁定美国对伊朗的制裁违反了两国1955年签订的《经济关系和领事权利友好条约》,初步裁决美国应立即停止针对伊朗人道主义物资及民航安全相关商品和服务的制裁。这时,美国才意识到自己先打脸,随即宣布终止该条约。美国国务卿蓬佩奥宣称,这是一个39年前就该作出的决定。美国以“莫须有”的罪名来对待一个法理上不沾边的公司,其推行国际霸权和强权政治的“长臂管辖”愈发站不住脚。

  作为主权国家的加拿大在执行美国司法申请时不可能不知情,可偏偏表示“这项决定当然没有涉及政治层面的参与,因为我们尊重司法程序的独立性。”这一表态让加拿大“司法独立”成为笑话和鬼话。难怪海外网民对加拿大政府“代美执法”行径深为不满,称“加拿大就是美国的一条忠犬!”、“原本以为加拿大是一个自由民主的国家, 现在看来不过是美国的仆人”、“为什么美国的制裁能够限制中国人跟伊朗的交易,还能在此人在加拿大时将其逮捕?”美国布鲁金斯学会历史学家罗伯特·卡根曾在《华盛顿邮报》撰文称“美国正在成为一个流氓国家”。看来,加拿大也加入了其中。

  其次,加拿大肆意践踏人权的做法暴露其人权领域的双重标准,它正在成为人权保护行动的破坏者,在损害世界的和平与稳定发展。

  《金融时报》援引美国一名前情报官员表示,逮捕孟晚舟的行动“太过激进”。在推特上,各国网民们对这一事件的评价是“绑架人质”、“不择手段”等。有网友质疑,“美国是怎么知道一个中国女人会从加拿大转机的呢?美国和加拿大是否只跟踪中国护照, 或者每一个美国人都被监视?”众所周知,加拿大是美国、英国、澳大利亚、加拿大和新西兰的情报机构联盟“五眼联盟”成员,成员内部实现情报信息与窃取数据的互联互通和共享。这就不难解答人们的疑问,也加重了人们的不安全感。更多人从孟晚舟被捕中感受到了基本人权被无情践踏的威胁,也不知有多少人进入了被“五眼联盟”要逮捕的名单中?西方自居的“人权卫士”又倒下一个。

  第三,这是一场针对中国科技领军企业的定向打击,加拿大在其中扮演“破坏者”的作用越来越明显。

  美国单方面制裁伊朗,加拿大政府是反对的。但当美国以此为借口对付华为时,加拿大便俯首帖耳、言听计从,其包藏的“祸心”和“私心”昭然若揭。华为作为中国乃至世界最优秀的移动通信基础设施供应商之一,在5G领域处于全球领先地位,拥有全球数一数二的专利和技术。但在“意识形态”作祟下,加拿大正成为阻碍华为全球发展的绊脚石甚至“破坏者”。据美国《华尔街日报》报道,加拿大安全情报服务负责人表示,外国干涉和间谍活动是加拿大繁荣发展和国家利益面临的“最大威胁”,加拿大或许会考虑禁止包括华为在内的一些“网络威胁活动”。面对中国企业的竞争优势,一些国家开始用政治手段设置障碍。有网民称,“如何赢得5G技术战?逮捕你的竞争对手!”。少数国家一面公开高喊“公平竞争”,一面私底下耍着扼杀和捣毁“公平竞争”环境的伎俩,试图保持自身竞争优势。但历史无数次证明,这样的挣扎徒劳无益,受害者总能从逆境中奋起,以更快的速度和更强的势头打破围堵,甚至能实现跨越式发展。

  第四,加拿大这一逮捕行为引发中国社会高度关注,加拿大的形象一落千丈。

  最近几天,中国网民普遍质疑和谴责美加的行径,声援华为,强烈要求释放孟晚舟。原本中国人对加拿大怀有好感,几乎每个中国人都知道加拿大医生白求恩当年来华帮助中国抗战的故事。中加1970年建交是在现任加拿大总理特鲁多的父亲皮埃尔·特鲁多的任内实现的。贾斯廷·特鲁多上任后,中国一度掀起“特鲁多热”,希望中加关系更上一层楼。2017年两国旅游互访规模超过150万人次并创下新纪录,2018年被定为“中国—加拿大旅游年”。

  国之交在于民相亲,失去民心就伤了两国交往的动力。加拿大这次逮捕和拘押孟晚舟女士,将给中加关系带来相当深远和持久的负面影响。

  孟晚舟事件不仅影响中加关系,也给世界带来不安。事件一出,全球股市与汇市遭遇震荡。加拿大这一鲁莽的拘捕行动,让各国朝野震惊,加剧了市场的担忧和恐慌情绪。加拿大非但捞不到好处、达不到目的,反而会“赔了夫人又折兵”。华为公司和中国政府的态度是理性克制,却又坚定坚决的。华为表示,相信加拿大和美国的法律体系会最终会给出公正的结论。中国官方表示,加拿大警方应美方要求逮捕一个没有违反任何美、加法律的中国公民,对这一严重侵犯人权的行为,中方表示坚决反对并强烈抗议。中方已向美、加两国进行了严正交涉,要求它们恢复孟晚舟女士的人身自由,并警告加方要承担由此造成严重后果的全部责任。

  "Release her immediately! Restore Ms. Meng Wanzhou’s personal freedom." This is a reasonable and legitimate request from Huawei and the Chinese government. I hope the Canadian government and judicial department, which stand at the crossroads, will not go further and further away from fairness and justice.

 

  "International Sharp Review: Canada as a Pioneer in the" **** "points out:

  Chinese Vice Foreign Minister Le Yucheng urgently summoned Canadian Ambassador to China John McCallum on Saturday (8th) to lodge solemn representations and strong protests against Canada’s detention of the head of Huawei. Le Yucheng pointed out that Canada’s detention of a Chinese citizen who was transiting in Vancouver, Canada, on the grounds of the request of the US, seriously violated the legitimate rights and interests of Chinese citizens, disregarded the law, was unreasonable and intolerable, and was of an extremely bad nature. China strongly urges the Canadian side to immediately release the detainees and earnestly protect the legitimate and legitimate rights and interests of the parties involved. Otherwise, serious consequences will be caused, and the Canadian side will bear full responsibility for this.

  In this "****" case, Canada’s behavior as a pioneer has caused many people to stumble.

  Just a few months ago, Canadian Prime Minister Justin Trudeau publicly criticized the United States for imposing tariffs on Canadian steel and aluminum products on the grounds of national security. He said that "Canadians are polite and reasonable, but we will not be pushed around." And he took countermeasures against the United States: not only launched a trade complaint against the United States through the World Trade Organization, but also imposed a 25% tariff on US imports worth $12.60 billion starting from July 1. At that time, international public opinion regarded Canada as a bloody man!

  可就是这样一条“不会被人摆布”的血性汉子,最近却扮演了一个很不光彩的角色,奉命拘押在温哥华转机的华为公司负责人。其行为令人不齿,更令人不安。

  美国知名财经记者诺切拉(Joe Nocera)在加拿大贝尔传播旗下的英文财经频道BNN Bloomberg上发文称,“我们有一个词来形容这种违反本人意志拘押某人、并对释放该人设置前提条件的行为,这个词叫做‘绑架’。这是流氓团伙干的,不应该是宣称依法治国的政府所为。”他指出,作为一家不在美国营业的中国企业,华为无须遵守美国对伊朗的制裁措施;即便华为通过一家在制裁名单上的银行同伊朗做生意,那过错也在该银行,而非华为;哪怕华为真的需要遵守美国的制裁措施,强制执行手段中也绝不包含拘押公司首席财务官这一条。诺切拉指出,所谓的违反了制裁规定的说法只是一种借口,因为《纽约时报》说了,拘押孟晚舟只是美国政府为限制中国技术向全球推广而发出的“一个警告”。

  渥太华一位名叫杜海尼(Alex Duhaney)的读者给加拿大最大的报纸《环球邮报》(The Globe and Mail)写信说,“我为我们的政府参与这一起绑架外国企业高管的行为感到深深的耻辱。如此无耻的行径已经令现在的领导层蒙羞,也将把那些在海外营商的加拿大人置于危险的境地。”

  近年来,一些西方国家一直不遗余力地在抹黑华为,污蔑华为是间谍,是潜在的巨大的信息安全隐患。但是,与其他西方国家不同,加拿大并没有禁止这家中国科技巨擘参与当地的重要项目。加拿大主要手机运行商的电信设施都有华为的产品,贝尔公司(BCE)与忒勒斯公司(Telus)都跟华为合作开发5G网络,一些加拿大高校也跟华为建立了伙伴关系。

  最近几个月,加拿大政府为了拓展自身的贸易市场,正加紧同中国接触,积极推动双边自贸协定的谈判。在同美国、墨西哥达成新的贸易协定后,媒体纷纷报道了美方在新协定中设置的针对中国的“毒丸”条款,对此,加拿大外长弗里兰(Chrystia Freeland)还特意给中国国务委员王毅打电话,亲自解释说加方将根据自身决定推进与其他国家的自贸协定谈判。加拿大70多位专家撰写了一份报告,为避开美国“毒丸”条款发展与中国的经贸关系建言献策。上个月,首轮中加经济财金战略对话在北京举行,加拿大财政部长莫钮(Bill Morneau)和国际贸易多元化部长卡尔(Jim Carr)与中国国务委员王勇共同主持。加拿大政府在声明称,“双方重申了进一步深化和扩大加中经济与贸易关系的承诺”。

  然而,这一切的努力以及已经建立起来的合作如今因拘押中国公司负责人而陷入困境。加拿大艾尔伯塔大学中国学院主任侯秉东(Gordon Houlden)表示,“整个事件对于我们而言是个坏消息”。经此一役,加拿大政府已经不太可能再让华为继续参与5G技术建设了,因为美国不会允许的。反过来,加拿大想同中国在某些领域达成自由贸易协议的目标恐怕也难以实现了。加拿大网友们哀叹,他们期盼的价廉物美的5G要泡汤了。不少人还呼吁加拿大法庭和政治家们要站起来,拒绝美国引渡华为公司负责人的要求。因为,所谓的“违法行为”根本就是政客们发明出来的罪名,目的是为了禁止其他国家/公司/个人之间的相互交易。这就是所谓的“莫须有”。

  希望加拿大的司法机构和政府在这场“政治绑架”事件中别把自己也给绑架了。

The BMW 3 Series in Changsha is on sale, with a minimum price of 209,900! limited in number

[car home Changsha Preferential Promotion Channel] Recently, a generous preferential promotion activity was ushered in in Changsha, with the highest preferential margin reaching an astonishing 120,000 yuan! Now, the minimum starting price is only 209,900 yuan. If you are interested in this luxury car, you may wish to click "Check the price of the car" in the quotation form to get a higher discount!

长沙地区宝马3系正在优惠,最低售价20.99万!数量有限

The design of BMW 3 Series is full of sense of movement and luxury. Its front face adopts the iconic kidney-shaped air intake grille with sharp LED headlights to create a highly recognizable visual effect. The body lines are smooth, and the overall style is compact and dynamic, showing the consistent high-performance genes of BMW brand.

长沙地区宝马3系正在优惠,最低售价20.99万!数量有限

The body size of BMW 3 Series is 4728*1827*1452 mm, the wheelbase is 2851 mm, the front tread is 1583 mm and the rear tread is 1568 mm.. From the side, its lines are smooth, the proportion of the car body is coordinated, and the front face and tail design reveal a sporty atmosphere. In terms of tires, the car is equipped with 225/45 R18 front tires and 255/40 R18 rear tires. With 18-inch wheels, it not only provides good grip, but also shows its sports style.

长沙地区宝马3系正在优惠,最低售价20.99万!数量有限

The interior design of BMW 3 Series is simple and full of scientific sense. The layout of the center console is reasonable. The 14.9-inch central control screen occupies the visual center, which supports multimedia system, navigation, telephone, air conditioner, window and other functions. It can be operated by voice recognition control system, providing a convenient car experience. The steering wheel is made of leather, which supports manual up and down+forward and backward adjustment, ensuring that the driver can find the most comfortable driving position. The front seat is made of imitation leather and has heating function. The main driver’s seat provides functions such as front and rear adjustment, backrest adjustment, height adjustment (4-way), leg rest adjustment and lumbar support (4-way). The co-pilot seat also supports front and rear adjustment, backrest adjustment, height adjustment (4-way) and leg rest adjustment to meet the needs of different passengers. In addition, the car is equipped with USB and Type-C interfaces to provide passengers with convenient charging options, and the front seats also have wireless charging function of mobile phones to further enhance the technological experience.

长沙地区宝马3系正在优惠,最低售价20.99万!数量有限

The BMW 3 Series is equipped with a 2.0T turbocharged engine, with a maximum power of 180kW and a maximum torque of 400 N m. With the 8-speed automatic manual transmission, the excellent performance of the vehicle in terms of power output and driving experience is ensured.

Car home car owners mentioned in the evaluation that the spatial performance of BMW 3 Series is quite satisfactory, which is in line with the positioning of B-class cars. Although some space has been sacrificed, as the main sports model, such spatial performance is enough. In contrast, he once considered CT5, but finally chose BMW 3 Series, thinking that it not only meets the sports performance, but also meets the satisfactory standard in space performance.

The 4th China Internet Media Forum (II): Main Forum

   From November 8 to 10, 2004, the 4th China Internet Media Forum was held in Nanchang, Jiangxi Province. The leaders of the central and provincial media websites, well-known portal websites and IT experts and scholars will deliver keynote speeches at the forum. At 2: 30pm on November 8th, China. com will continue to broadcast live through pictures, texts and videos.

Tesla FSD officially increased its price to $15,000 without adding new features.

On September 6th, according to the previous statement of Tesla CEO Elon Musk, the company has recently officially raised the price of the fully automatic driving (FSD) package of the advanced driver assistance system to 15,000 US dollars (about 103,900 yuan).

According to foreign media reports, some people believe that this FSD system is not worth $15,000 at present. ; Although it costs $9,000 more than the enhanced version of Autopilot, users only have the opportunity to experience the latest beta version of FSD.

Over the years, Musk has always said that with the continuous improvement of the functions of the FSD system, the car will eventually be fully autonomous. Tesla will also gradually increase the price of this system.

. Although the test has been carried out for two years, there is still a long way to go to realize the full automatic driving of the car.

From a technical point of view, the FSD system can run in most traffic environments, including crossing intersections, but the responsibility for driving still lies with the driver, who still needs to keep his attention and be ready to take over control at any time. The industry believes that the most important step for companies developing autonomous driving systems to achieve this goal is to be willing to assume the driving responsibility under the activation of the system.

Tesla has made it clear that this cannot be done. The company sent a series of warnings to users who participated in the FSD Beta test, clearly indicating that the driving responsibility still lies with the driver.

Tesla believes that every update of the FSD system means a step closer to the goal of fully autonomous driving, and that some of these updates are worthy of raising the overall price of the system.

Last month, Musk also reported that Tesla would increase the system price from $12,000 to $15,000 as the company launched the beta version of FSD Beta 10.69 on a larger scale.

On Monday, Tesla updated the price information of FSD on the vehicle customization page in official website-by $3,000-but did not include more new features. There are more words such as "coming online" and "automatic turning on urban roads" in the description of the page, which is still in the testing stage open to invited users, and it is not much different from the previous routine update.

source map

source map

If the user already owns Tesla’s enhanced Autopilot system, there is nothing new except the opportunity to experience the latest beta FSD, and the test experience itself is not a reward.

Musk has made it clear that the value of a fully autonomous driving system far exceeds $15,000. He said that the price would continue to rise. In fact, the initial price of the FSD system was only $6,000. Now, what you buy with an extra $9,000 is not what users really want, but that you can bet on Tesla to provide real automatic driving function in the future, and you can start at a lower price.

However, it is not clear how Tesla can develop the beta FSD into a safe autopilot system that is willing to take responsibility.

Official announcement! Five pharmaceutical companies in China obtained the license for free imitation and production of Pfizer COVID-19 oral medicine.

  The market rumors of Pfizer COVID-19’s oral medicine imitation license have been confirmed.

  On March 17th, official website, a pharmaceutical patent pool (MPP), announced that it had signed agreements with 35 companies, which were allowed to copy and produce nirmatrelvir, one of the ingredients of Paxlovid, an oral drug of Pfizer COVID-19.

  According to the map released by official website, the countries involved in the agreement are distributed in 12 countries around the world, among which 6 companies will focus on the production of APIs, 9 companies will produce drugs, and the remaining 20 companies will have both. There are five pharmaceutical companies in China, including Huahai Pharmaceutical (600521), Puluo Pharmaceutical (000739), Fosun Pharmaceutical (600196), Jiuzhou Pharmaceutical (603456) and Shanghai Disino, among which Jiuzhou Pharmaceutical only produces APIs, while others can produce APIs and preparations at the same time.

  It is worth noting that the agreement will help to expand the accessibility of Pfizer COVID-19 oral medicine in 95 low-and middle-income countries, accounting for about 53% of the world population, but excluding China.

  Earlier on March 17, the above news was circulated in the market, and the above listed companies once had a daily limit. Previously, it was rumored in the market that Puluo Pharmaceutical could only produce APIs. According to the newly published map, Puluo Pharmaceutical can produce both raw materials and preparations.

  It is worth noting that a Ukrainian company is also on the list of 35 companies. MPP said that due to the current conflict, it could not be signed, but the license could still be used.

  According to the data of official website, the Pharmaceutical Patent Pool Organization is a public health organization supported by the United Nations, which is committed to increasing access to life-saving drugs for low-and middle-income countries and promoting drug development.

  On January 20th, local time, the Pharmaceutical Patent Pool Organization (MPP) announced through official website that it had signed an agreement with 27 pharmaceutical companies to allow them to produce and supply the oral anti-Covid-19 drug Molnupiravir of Merck to 105 low-and middle-income countries or regions around the world, so as to promote the affordability and accessibility of the drug in the world. Five China pharmaceutical companies, such as Fosun Pharma, Borui Pharma, Shijiazhuang Long Ze Pharmaceuticals, Shanghai Diseno and Langhua Pharmaceuticals, are among them, of which the first four are allowed to produce both raw materials and finished products, and Langhua Pharmaceuticals is allowed to produce raw materials.

  In other words, two pharmaceutical companies, Fosun Pharma and Shanghai Disino, have obtained the rights to prevent and control the production of Pfizer and Merck.

  Pfizer’s Paxlovid is a combination of PF-07321332 and ritonavir, which has been approved for conditional marketing in China. Molnupiravir of Merck is a nucleoside drug in oral form, which has not been approved in China.

Mycoplasma pneumonia is threatening, and adults and children may get sick. How should we deal with it?

CCTV News:Recently, the number of patients infected with mycoplasma pneumoniae has increased in many places, especially in children, and the treatment time is long. Many patients and their families have questions. Why is it not good after treatment for a while? I’ve already hit pneumonia vaccine, why can I get mycoplasma pneumoniae pneumonia? How to prevent uninfected people?

Hao Hongwen, chief physician of Pediatrics, Oriental Hospital, Beijing University of Chinese Medicine, gave the following answers to nine common questions about mycoplasma pneumoniae pneumonia.

Question 1: Why did you get mycoplasma pneumonia after playing in pneumonia vaccine?

Hao Hongwen:This is actually a question that we often answer parents in clinic. Usually, children and the elderly are vaccinated with pneumonia vaccine, which is mainly aimed at Streptococcus pneumoniae. However, the pathogen of this popular pneumonia is Mycoplasma pneumoniae, and there is no vaccine against Mycoplasma pneumoniae at present. Therefore, even if vaccinated with pneumonia vaccine, pneumonia caused by Mycoplasma pneumoniae cannot be prevented, because the pathogen is different. Of course, pneumonia vaccine has positive significance in preventing pneumonia and other diseases caused by Streptococcus pneumoniae.

Question 2: I went to check my blood when I had a fever and cough. The antibody against Mycoplasma pneumoniae was also negative, but not positive. Why did it eventually become Mycoplasma pneumoniae pneumonia?

Hao Hongwen:This is because the most positive time of mycoplasma pneumoniae antibody is 5-7 days after infection, so the initial examination may be negative, and some of them will be false negative. Therefore, negative antibody to mycoplasma pneumoniae can not rule out mycoplasma pneumoniae infection.

Question 3: What are the characteristics of mycoplasma pneumonia? How to identify?

Hao Hongwen:Pneumonia caused by mycoplasma infection is characterized by "double weight and light weight".

First of all, the symptoms are serious. Children mainly have a severe fever and cough, and most of them will continue to have a high fever, or the low fever will continue all the time, and the cough will be very heavy. In the first day or two of the onset, the cough may not be obvious, and then the cough will gradually become obvious, mainly manifested as paroxysmal and irritating cough, that is, coughing up in a big array, and even coughing badly will vomit and shed tears. This kind of cough, often with little phlegm at the beginning, is characterized by dry cough, and phlegm will appear in the middle and late stage of the course of the disease, which is the "first weight".

Although this kind of pneumonia has a severe fever and cough, the rales of the lungs are often not heard in the early and middle stages of the disease. Therefore, there is no dry and wet rales after the doctor auscultates the lungs. In layman’s terms, it is no problem to auscultate the lungs. This is a "light".

The characteristic of this disease is twofold and lightness, and the "second weight" is that the chest radiograph is heavier. If a child has a fever for more than three days, high fever for more than three days or low fever repeatedly, and his cough gradually worsens for more than three or four days, he must also consider this kind of pneumonia. Although there is no obvious abnormality in auscultation, doctors will generally advise the child to take a chest film to see if there is any pneumonia. The chest film may show signs of lung inflammation, some of which may be patchy, some may even be large white consolidation, and even pleural effusion. This is the "second weight".

Therefore, we simply sum up the characteristics of mycoplasma pneumoniae pneumonia as "double weight and light weight". If parents and friends find that their children have such characteristics of fever and cough, they must also pay attention to the possibility of mycoplasma pneumoniae pneumonia, and if necessary, conduct chest X-ray or even chest CT examination under the guidance of a doctor.

Question 4: How is Mycoplasma pneumoniae infected? How to prevent it?

Hao Hongwen:The infection of mycoplasma pneumoniae is the same as our common respiratory infections, and it is mainly transmitted through the mouth and nose, so it is easy to be infected in crowded places or in close contact with patients if no protective measures are taken. Therefore, in view of this route of infection, we still have to emphasize that children should go to crowded, closed and unventilated places as little as possible. If the disease is at a high incidence, it is recommended that children wear masks as much as possible and wash their hands frequently when going to these places. Of course, it is necessary to have enough sleep, a reasonable diet, and timely increase or decrease clothes according to the weather conditions, so as to enhance the child’s resistance and avoid the infection of mycoplasma pneumoniae. If someone in the family has been infected with mycoplasma, try to wear a mask or live in a separate room, and open the window frequently for air at home. Especially for families with two children, it is particularly easy to infect each other.

Question 5: Pneumonia only affects the lungs. Will there be other complications?

Hao Hongwen:Mycoplasma pneumoniae pneumonia, its impact on the human body is relatively extensive. The mild pneumonia will gradually recover after a few days of medication, and it will have a greater impact on the severe pneumonia or the pneumonia with long fever time and heavy lung imaging. The common complications are divided into two parts: intrapulmonary and extrapulmonary. The intrapulmonary complications include plastic bronchitis, embolism (which can be independent or combined with other parts), pleural effusion, and some children may be complicated with acute asthma attack and mixed lung infection. Extrapulmonary, including nervous system, circulatory system, blood system, skin, liver damage, kidney damage, etc., among which myocarditis, myocardial damage and liver damage are more common, and in addition, in the nervous system, encephalitis may be common. Skin complications will have some rashes, and the blood system may have some changes in blood cells such as platelets. Each system will also have serious complications, even life-threatening, so we can’t take it lightly.

Question 6: Why did the symptoms get worse after taking cephalosporin from the beginning?

Hao Hongwen:This is because penicillin and cephalosporins play a role by inhibiting the synthesis of cell walls, but when mycoplasma pneumoniae is infected, mycoplasma pneumoniae has no cell walls, so cephalosporins can’t play a role. The use of macrolides such as azithromycin or erythromycin mainly inhibits the synthesis of protein, thus inhibiting the activity of mycoplasma and playing an anti-infection role. Therefore, if mycoplasma pneumoniae is infected, cephalosporins are ineffective. However, some patients may be complicated with bacterial infection and also use cephalosporins.

Question 7: Mycoplasma pneumoniae pneumonia, how should it be treated?

Hao Hongwen:If it is mycoplasma pneumoniae pneumonia, it is generally divided into mild and severe. Mild pneumonia is treated with macrolides such as azithromycin for three days, which may be extended to five days according to the condition, or cyclic erythromycin and roxithromycin can be used. At the same time, you can use some drugs to relieve cough and phlegm. Traditional Chinese medicine can generally use Shegan Mahuang Decoction and Maxing Shigan Decoction after syndrome differentiation.

Severe mycoplasma pneumonia is mainly treated with azithromycin for 7 days, and then stopped for 3-4 days. According to the situation, a second course of treatment or a third course of treatment may be needed, with cough relieving, phlegm resolving, aerosol inhalation, etc., and anticoagulation treatment if necessary. Chinese medicine can be treated with Maxing Shigan Decoction combined with Sanzi Yangqin Decoction and Huanglian Jiedu Decoction. In this process, if the symptoms are not relieved, fever or severe cough persist, it is necessary to consider whether it belongs to drug resistance, mixed infection or other complications according to the situation, and consider switching to other antibiotics, adding hormones, combining antibiotics, bronchoscopic lavage, immunoglobulin and other treatments. This needs the doctor to decide according to the situation.

Quinolones are the first choice for adult treatment, as well as new tetracyclines.

In short, each patient’s situation is different. Under the guidance of treatment principles, specific problems are analyzed and solved. During the period, children should drink water properly, atomize to dilute sputum, and eat digestible food.

Question 8: Why did you use azithromycin and erythromycin, but your condition still hasn’t improved?

Hao Hongwen:This is because the improvement of the disease is related to the following factors: the first is to feel the virulence of this pathogen, the second is whether our body’s resistance is moderate (too weak or too strong), and the third is whether the drug is resistant. If you feel that the pathogen is more virulent, the child’s immunity is weak or too strong, then the drug is not enough to weaken the pathogen or inhibit the excessive immune response, so even the drug can not quickly inhibit the development of the disease. Mycoplasma pneumoniae pneumonia can be divided into mild pneumonia and severe pneumonia, as well as refractory mycoplasma pneumonia. It refers to that after 7 days of treatment with regular macrocyclic lipid antibiotics such as azithromycin, the clinical symptoms and signs or imaging examination have not improved, or other complications have occurred. This year’s guide in 2023 also mentioned "macrolide nonreactive mycoplasma pneumonia", which means that the condition has not improved after 72 hours of treatment with regular macrolide drugs. If drug resistance is considered, new tetracycline drugs such as doxycycline and minocycline can be selected. These drugs are suitable for children over 8 years old, and those under 8 years old are beyond the instructions, which need full evaluation and informed consent of parents. So it is also mycoplasma infection, but the development and changes of the disease are different because of different factors. However, this kind of refractory pneumonia or unresponsive pneumonia is often easy to develop into severe pneumonia. In addition to antibiotic treatment, it is often necessary to cooperate with a variety of therapeutic drugs and means.

Question 9: In the late stage of mycoplasma pneumoniae infection, the child has a bad appetite and a persistent cough. What should I do?

Hao Hongwen:Some children with mycoplasma pneumoniae pneumonia still have some cough symptoms after 2-3 courses of anti-infection treatment, or at the later stage of disease treatment, the children show poor appetite and cough with persistent phlegm. At this time, considering that there may be airway hyperresponsiveness or other sequelae from western medicine, we can continue to adopt corresponding treatment and atomization. Traditional Chinese medicine treatment also has advantages. Traditional Chinese medicine believes that the residual evil is not exhausted and the healthy qi has been injured in the later stage of the disease. Traditional Chinese medicine is used to clear the residual evil and help the healthy qi. At the same time, some other treatments of traditional Chinese medicine, such as cupping and massage, can be used to assist the recovery of pneumonia. (Reporter Yan Yan)

Jiangsu has added 16 national-level non-legacy projects! How much do you know about these "national names"? Xiao Xiaosu said

  Intangible heritage is the "living" soul of traditional culture, a precious memory of national traditional culture, bearing cultural awareness and national spirit. Jiangsu is one of the cradles of ancient civilization in China, with numerous intangible cultural heritages. Recently, the State Council announced the fifth batch of national intangible cultural heritage representative projects and expanded projects, and 16 projects including Jiangsu Nanzha Folk Song and Taixing Flower Drum were selected. (Please poke the directory for details > >)

  How much do you know about these non-legacy projects? Feel their charm with Xiao Su!

   | The Fifth Batch of National Intangible Heritage Representative Projects in Jiangsu Province

  Huaian: Nanzha Folk Songs

  Nanzha folk song is a traditional folk song in Jiangsu Province. Nanzha Town is located in the southwest border of Chuzhou District, Huai ‘an City, with the Grand Canal in the east and Baima Lake in the vicinity. It has beautiful scenery and rich humanities. It is not only full of the cultural charm of the Beijing-Hangzhou Canal, but also rich in rich and high-quality local folk songs. Nanzha folk songs born of the canal originated from this place.

  According to historical records, Nanzha folk songs were well-known in the Tang Dynasty. Nanzha folk songs, based on their rich rhyme of water and countryside, have formed euphemistic, slow and lyrical singing features and singing forms such as competition and duet, and more than 500 songs have been circulated so far.Covering folk music, folk literature and folk culture, it is rich in content, beautiful in melody, widely sung and well protected, and is known as the "living fossil of folk traditional music". As early as 2009, Nanzha folk songs were listed as provincial intangible cultural heritage projects.

  Taizhou: Taixing Flower Drum

  Taixing Flower Drum originated from Qinjialou, Nansha Township, Guangling District, Taixing County, according to Mingzhai Zhenshi • It has a history of three or four hundred years. Taixing Flower Drum can not only perform dance alone, but also sing while dancing. Whether it is the dance itself, the tune or the lyrics, it has a complete and mature structure, unique style, self-contained and extremely local characteristics.

  Taixing Flower Drum is sung in Taixing dialect, and the lyrics are not fixed. In order to avoid monotonous repetition, some lyrics are often made up and filled into the song, or some humorous and witty songs are sung to enliven the atmosphere and please the audience. The dance steps and movements of Taixing Flower Drum are large, flexible and funny. The dance steps include "Three Steps Upside Down", "Magpie Climbing the Plum Step" and "Jade Rabbit Yue Bai Step". Among them, "Three Steps Upside Down" and "Magpie Climbing the Plum Step" are not found in other folk dances. In particular, the "three-step", the foot shaking and the waist twisting and knees bending, is very rhythmic, showing the simple, kind, optimistic and cheerful personality of Taixing people. In 2009, it was listed as a non-legacy protection project in Jiangsu Province.

  Suqian: Subei Drum

  Subei Drum is a form of rap music based on Suqian dialect, commonly known as "singing big books". The form of expression is a big drum and two crescent plates. Talk and sing, and pay equal attention to rap. His lyrics are rigorous, including cross sentences, seven sentences, five sentences and three sentences. To put it bluntly, pay attention to drinking, eating, being slow and anxious, with symmetrical upper and lower sentences and vigorous singing. The long representative works are Gao Huaide’s Soldiers Going Down to Hedong, A Loyal Luo Family General, and the short representative works are Yu Ji’s Ci Chu, Aunt’s Pledge, Giving Sheep, Flying Kite, etc.

  Northern Jiangsu Drum was formed in the middle of Qing Dynasty, and it was recorded in detail in China Quyi Zhi. Mainly distributed in Suqian, Jiangsu, Suining, Pizhou and other areas along the Beijing-Hangzhou Grand Canal, and then extended to Huai ‘an, Lianyungang and other surrounding areas. Northern Jiangsu drum works have won many national and provincial awards such as Peony Award nomination award, Wenhua Award, Five-Star Project Award and Luhua Award.

  Yancheng: Hair Embroidery (Dongtai Hair Embroidery)

  Dongtai Hair Embroidery, formerly known as Ink Embroidery, is made of silk as the base, embroidery needle as the pen, and selected girls’ natural hair as the embroidery thread. Compared with other embroidery crafts, hair embroidery is a comprehensive art with unique materials, corrosion resistance, strong texture, never fading, simple and elegant, pale and beautiful, natural color, involving books, paintings, printing, embroidery, engraving and many other fields. In 2007, Dongtai was named as "the hometown of hair embroidery art in Dongtai, China" by China Folk Writers Association. The Ministry of Culture has twice named "Dongtai Hair Embroidery" as the hometown of folk art.

  Dongtai hair embroidery originated in the Tang Dynasty with a history of more than 1300 years. Through the inheritance and innovation of outstanding hair embroidery craftsmen in the past dynasties, the variety has developed from the original ink embroidery to touch-up embroidery, Shuang Mianxiu embroidery and double-sided embroidery with different colors, which further improves the viewing effect and enhances the appeal of the works. On the basis of inheriting the traditional needling methods, more than 30 kinds of needling methods, such as rolling, spinning, winding and sleeving, are expanded, which are used flexibly according to different works, making the shades, wet and dry, distance and depth of the works more natural and enriching the expressive force of hair embroidery works.

  Lianyungang: Crystal Sculpture (Donghai Crystal Sculpture)

  Crystal carving in the East China Sea has a long history. In the 1970s, the "Crystal Gravel Scraper" unearthed at Daxianzhuang Site in Shanzuokou, Donghai County was the first Paleolithic site discovered in Jiangsu Province. The craft mainly includes "round carving, relief carving, through carving, line carving, reverse carving, female carving, male carving and other techniques."

  Based on rock crystal’s texture, size, shape, color, inclusions, water bladder and other characteristics that other jade does not have, Donghai Crystal Sculpture is characterized by its crystal clear, colorful modeling, exquisite and unique patterns and exquisite carving skills. It is constantly "recreated" by adopting modern cultural and artistic methods such as knowing and vivid, homophonic borrowing, painting and seal cutting combination, and inlay and embellishment, forming a unique national traditional style, which has artistic value of the times and has won successively. Donghai Crystal Festival ",the 8th Jiangsu" Crystal City Cup "Crystal Sculpture Grand Prix.

  Yancheng: Porcelain Carving (Dafeng Porcelain Carving)

  Porcelain carving is a traditional folk handicraft art with a long history in China, and there were methods of peeling and chiseling porcelain glaze in Qin and Han Dynasties. Since the Wei and Jin Dynasties, with the development of the ceramic industry, a large number of exquisite porcelains appeared. While enjoying porcelains, emperors, officials and some literati wanted to keep the ink of poems and inscriptions on them for permanent preservation, so artists at that time carved the outlines of poems and paintings on the porcelain blank before glazing with a straight knife, which formed the initial porcelain carving. According to legend, Emperor Qianlong of the Qing Dynasty often inscribed poems on his favorite porcelain to express his passion. In order to keep the imperial vestiges for a long time, court artists tried to carve Mo Bao on porcelain, which really produced porcelain carving.

  Dafeng porcelain carving is famous for its exquisite knife work, smooth lines, far-reaching artistic conception and vivid figure carving. It takes porcelain as the carrier, steel chisel and hammer as tools, and uses the unique beauty of porcelain itself and the porcelain collapse effect after carving, combining the carving techniques of different shades, different densities, uneven lengths, coarse and fine, virtual and real with the knife method, and vividly reproduces the object mechanism of the works on the surface of porcelain, which not only

  Yangzhou: Powder making skills (Xie Fuchun powder making skills)

  Xie Fuchun fragrant powder shop was founded in the tenth year of Qing Daoguang (1830), and it is famous for its "fragrance, powder and oil". Its production technique is a special technique of picking the fragrance from flowers, injecting raw powder and oil, supplemented by other materials such as traditional Chinese medicine, and processing through multiple technological processes, so as to make fragrant powder, fragrant pieces and comb oil. This technique is very complicated and has profound cultural implications.

  As early as 1915, Xie Fuchun’s duck egg powder and xiang zhu won the gold medal at the first Panama Pacific World Expo held in 1915. During the Republic of China, the development of Xie Fuchun’s powder making technique reached its peak. The inheritance, protection and development of Xie Fuchun’s production skills of "fragrance, powder and oil" are of great significance to the study of local craft history and even the history of China folk culture and beauty culture.

  Xuzhou: Xuzhou fuyang food custom

  "Fu Yang", that is, mutton after crouching, has been circulating in Xuzhou folks that "a bowl of mutton soup is crouched without a prescription from a fairy". It is believed that eating mutton in the dog days is a pioneering work of taking food as a treatment, which is to heat the body, sweat and detoxify, and drive away the poison and moisture in winter and spring.

  "Eating mutton in the dog days" has a long history in Xuzhou, which can be traced back to the Yao and Shun period. Xuzhou was called Pengcheng in ancient times, and Geng Keng was also called Peng Zu because of his seal in Pengcheng. Because Peng Zu was good at preparing delicious pheasant soup and giving it to Emperor Yao, he was sealed by Emperor Yao in Dapeng. Peng Zu’s famous dish "Sheep hide fish" and the roast mutton on the painted stone in Han Dynasty all show that Xuzhou people have a civilization history of thousands of years. In recent years, Xuzhou summed up and created the festival "Fu Yang Festival" on the basis of folk food customs, which started on the first day of the traditional lunar calendar every year and ended at the end of the last day, lasting for one month.

   | The fifth batch of national non-legacy representative projects expansion projects in Jiangsu Province

  *The expansion project of intangible cultural heritage representative projects refers to the project that has entered the last batch of national intangible cultural heritage projects before, but in the subsequent batch of declaration, due to the different reporting areas and units, the declared projects can only be regarded as the expansion list projects in the form of extended protection units.

  Taizhou: Stone Lock (Hailing Stone Lock)

  Stone locks are said to have originated from the military camp in China in the Tang Dynasty. Soldiers often use stone locks and stone burdens to exercise, and then spread to the people, and evolved into a traditional competitive event that integrates strength, skills and fitness.

  There are mainly snatch and swing lifting methods in Hailing’s stone dumping, and there are various kinds of colorful movements by throwing methods such as forward throwing, backward throwing, cross throwing and back throwing, and hand joint, finger joint, elbow joint, shoulder joint and head joint. Stone locks can be practiced by one person or by two people, and there are two or three people in the competition.

  Changzhou: Suzhou embroidery (Changzhou random needle embroidery)

  "Take the needle as the pen and the silk as the painters, seize the first voice of Suzhou embroidery, and climb the peak of embroidery art.. Everyone who sees it is praised as ‘ Shenzhen ’ 。” Liu Haisu, a famous painter, once had such an evaluation on the random needle embroidery. Different from the four famous traditional embroideries in China, the disorderly needle embroidery is a new embroidery art created by combining painting theory with embroidery theory, which was founded by Changzhou embroidery craftsman Yang Shouyu in the 1930s. Because of its unique embroidery method, it is called the fifth famous embroidery in China today.

  There is a description in Changzhou City Records: "Yang Shouyu’s disorderly needle embroidery art borrows needles to paint. All portraits, figures, landscapes, flowers, animals, birds and still life can be embroidered, especially figure embroidery, which is called ‘ Shenzhen ’ 、‘ Needle painting ’ " . The most striking feature of "random needle embroidery" is that it gets rid of the traditional operation method of "closely connecting its needles and arranging its lines" and does not stick to dogma, so that the author can freely express his thoughts and feelings. In 2007, random needle embroidery was selected into the first representative list of intangible cultural heritage in Jiangsu Province.

  Nantong: Carpet weaving technology (Rugao silk carpet weaving technology)

  Rugao silk carpet is a silk carpet craft with a history of more than 2,000 years, and it formed a local unique traditional manual craft in the late Ming and early Qing dynasties. Its uniqueness lies in the fact that it is the only tapestry artwork made by silk tapestry technology in China, which has typical cultural creativity value.

  Tapestry of Tianshan Mountain in Xinjiang Hall of the Great Hall of the People

  Rugao silk tapestry takes high-quality wild spun silk as raw material, and achieves special effects such as screen color separation, color matching, rhyme color and color jumping by a unique hand-knotting method, thus making the tapestry accurate in modeling, rich in expressive force, concise and thick in color, and fully showing the artistic characteristics of various schools of painters’ works, which is widely appreciated and valued by the art world.

  Rugao tapestry "Beijing Millennium Landscape Map"

  Suqian: Traditional Distilled Liquor Brewing Technique (Yanghe Liquor Brewing Technique)

  Yanghe liquor brewing technology began in the Tang Dynasty and developed in the Ming and Qing Dynasties. It has a history of more than 400 years and is a traditional distilled liquor brewing technology in China. Yanghe liquor has a unique brewing technique, which has been continuously improved in inheritance and development for hundreds of years and is still in full use today.

  Yanghe wine is completed by four processes: koji-making, brewing, sealing and blending. Its main characteristics are slow brewing by hand, three low technologies and soft taste. There are "four slowness" in manual slow brewing, that is, slow manual, slow fermentation, slow storage and slow production. After hundreds of years of production practice, a unique production process of Laowu retort was created, and the process and wine style could not be copied in different places. From grain selection, koji-making, brewing, wine storage, manual slow brewing, "slow kung fu" achieves "soft taste in no hurry" The "three low" processes are low-temperature entry into the pool, low-temperature fermentation and low-temperature distillation, which are the core techniques of Yanghe wine brewing. Yanghe liquor has a soft taste, which has the characteristics of "sweet, soft, clean and fragrant", creating a new pattern of "taste-oriented" and being praised as the "soft originator" of China liquor.

  Nanjing: green tea making skills (yuhua tea making skills)

  Shaped like a pine needle, it is tight, thin, round and straight, with beautiful front seedlings, green color, white dew, elegant aroma, fresh taste and bright green leaves … … Yuhua tea is one of the top ten famous teas in China. Nanjing green tea production has a long history, which is recorded in Lu Yu’s Tea Classic. Up to now, there is still an old trail of "Tea Trial Pavilion" behind the mountain of qixia temple. By the Qing dynasty, the scope of tea cultivation in Nanjing had expanded to the north and south of the Yangtze River. After the founding of New China, Yu Yongqi, a senior engineer of Sun Yat-sen Mausoleum, was responsible for the implementation of tea frying technology, which was successfully developed in the spring of 1959 and named "Yuhua Tea" to make the martyrs last forever.

  On the basis of inheriting the frying technology of ancient Chinese green tea, Yuhua tea has its own unique frying technology and incorporates new vitality, but the production process is complex, demanding and difficult. Nanjing has established a sound management organization while increasing investment, so that Yuhua Tea can be better inherited and developed.

  Nanjing: vegetarian cooking skills (green willow house vegetarian cooking skills)

  At the beginning of the last century, a vegetarian shop with only three or five tables and chairs opened in Taoyedu. The reason is that the vegetables are green in color, the willows are easy to live and grow, and the cloud "weeping willows are everywhere", hence the name "Green Willow House". With the change of wind and rain, Lvliu Jusu Restaurant has changed its name, changed its address and changed its chef several times. However, in the past 100 years, it has absorbed the essence of Chinese vegetarian culture and gathered the essence of vegetarian cooking from various factions to form an "old brand" of catering that integrates palace, temples, folk vegetarian food and exquisite halal dishes.

  The raw materials of Lvliuju vegetarian cooking are nothing more than "bean products, gluten, bamboo shoots, mushrooms" and all kinds of vegetables, but after careful cooking and continuous innovation by the inheritors, it has finally become a vegetarian dish with good color, fragrance, taste and shape, which is not only vivid in image, but also similar in taste. In the past hundred years, the vegetarian diet in Green Willow House has attracted many people to taste it and become a symbol of vegetarian culture in Nanjing, a famous historical and cultural city.

  Nantong: Traditional Chinese Medicine Preparation Method (Wang Baobao’s Akamaru Production Technique)

  Wang’s Bao Akamaru is a traditional Chinese patent medicine made by Wang Yiqing, the 17th generation descendant of Nantong Wang’s family of traditional Chinese medicine, in Daoguang period of Qing Dynasty. In 1956, his grandson, Mr. Wang Mianzhi, a famous TCM doctor and master of traditional Chinese medicine in Nantong, presented the secret recipe to the country, and the method was handed down by one of the predecessors of essence pharmaceutical Group — — Nantong Pharmaceutical Factory produces exclusively, and its technological formula has been listed in the national confidential formula list for more than 60 years.

  Wangshibao Akamaru is a pill made of all natural Chinese medicinal materials. The pill shape is as small as rapeseed, and the pills are symmetrical and round, and the luster is as bright as pearls. It has a unique effect in treating gastrointestinal diseases such as weakness of spleen and stomach, anorexia, diarrhea and constipation. In 1983, this famous medicine won the National Quality Silver Award, and then Wang’s Akamaru production skills entered the ranks of the intangible cultural heritage of the province.

  Suzhou: Temple Fair (Shengtang Temple Fair)

  The temple fair of Shengtang, known as the Spring Festival, originated in the early Jiajing period of Ming Dynasty, and is a folk cultural activity circulating in Yangcheng Lake area, mainly focusing on the three days from March 26th to 28th of the lunar calendar every year (the legend is the birthday of Dongyue the Great).

  The temple fair in Shengtang is large-scale. During the temple fair every year, people in Yangcheng Lake Town and its surrounding areas will spontaneously organize folk teams. After offering sacrifices to the local land gods, they will carry out Lu Yun, valiant generals and other temple gods in eight-lift sedan chairs, and walk slowly while playing strings. This folk cultural activity was listed in the municipal intangible cultural heritage list in June 2013 and the provincial intangible cultural heritage list in January 2016, which is of positive significance for inheriting the roots of national culture and enhancing the self-confidence of national culture.

  (My Su Net is integrated from Huaihai Evening News Wisdom Taixing Sucheng Cultural Center Dongtai Daily Happiness Dongtai Yancheng Released Non-legacy Yangzhou Xuzhou Released Xuzhou Wenguang Tourism Bureau Official Weiwei Hailing Taizhou Hailing Cultural Center Wenlv Changzhou Rugao Released Suqian Released Yanghe Net Local Records Jiangsu Traditional Chinese Medicine Nantong Released Suzhou Non-legacy Pictures and videos are all from network editors/Moka Fang)

Case inventory: Which officials and units have been notified by CPC Central Commission for Discipline Inspection to interfere with the inspection?

  People’s Daily Online, Beijing, July 12 The website of the Supervision Department of the Central Commission for Discipline Inspection reported on the 11th that Chang Xiaobing, the former party secretary and chairman of China Telecom Group Company, was expelled from the Party membership and public office, and his disciplinary problems included serious violation of political discipline and interference with the special inspection work of the central government. According to the investigation, since the implementation of the Regulations on Inspection Work in the Communist Party of China (CPC) in August, 2015, except Chang Xiaobing, CPC Central Commission for Discipline Inspection has notified many officials and units of cases of obstructing and interfering with the central inspection work.

  Deputy Secretary of the former Party Group of China Southern Airlines Group Corporation,General manager si xianmin

  Notification time: February 3, 2016

  Notification content: After investigation, Si Xianmin seriously violated political discipline, interfered with the inspection work, and seriously violated the spirit of the eight central regulations, playing golf with public funds. Serious violation of organizational discipline, failure to truthfully report personal matters as required, serious violation of integrity discipline, accepting gifts and cash gifts, using his authority to seek benefits for others, and his son accepting property and using his authority to seek benefits for relatives’ business activities. Approving the company to pay public funds to others in violation of regulations. Take advantage of his position to seek benefits for others and accept property in business operations. Among them, taking advantage of his position to seek benefits for others and accepting property is suspected of accepting bribes.

  Zhou Laizhen, former member and deputy director of the Civil Aviation Administration of China

  Notification time: January 19, 2016

  Contents of the notification: After investigation, Zhou Laizhen seriously violated political discipline, interfered with and hindered the inspection work, and resisted the organization review; Serious violation of organizational discipline, taking advantage of his position to seek benefits and accept property for others in the selection and appointment of cadres, illegally intervening in personnel arrangements of relevant units, failing to hand in personal passports and truthfully reporting personal matters as required; Seriously violating the discipline of honesty, handing over the expenses that should be paid by individuals to subordinate units or others, accepting gifts and cash gifts, taking advantage of his position to seek benefits for relatives’ business activities, and engaging in power trading; Serious violation of the spirit of the eight central regulations, illegal possession and use of golf cards, acceptance of over-standard public banquets, and acceptance of tours arranged by subordinate units; Seriously violating work discipline and changing the route without authorization during going abroad; Take advantage of his position to seek benefits for others and accept property in business operations. Among them, taking advantage of his position to seek benefits for others and accepting property is suspected of accepting bribes.

  Deng Qilin, former Party Secretary and Chairman of WISCO Group

  Notification time: January 8, 2016

  Contents of the notification: After investigation, Deng Qilin seriously violated political discipline, interfered with and hindered the inspection work, opposed organizational review, and engaged in superstitious activities for a long time; Serious violation of organizational discipline, illegal selection and appointment of cadres, taking advantage of his position to seek benefits and accept property for others in the selection and appointment of cadres, failing to truthfully report personal matters according to regulations, and failing to truthfully explain problems to the organization when talking; Serious violation of integrity discipline, taking advantage of his position to seek benefits for others and accept property in business operations, taking advantage of his position to seek benefits for relatives’ business activities, occupying houses in violation of regulations, receiving bonuses in violation of regulations, and occupying hotel rooms for personal use for a long time; Seriously violate the discipline of the masses, work discipline and life discipline, and trade power and sex. Among them, taking advantage of his position to seek benefits for others and accepting property are suspected of accepting bribes.

  Hu Zhengming, former director of the Party Committee Office of China Export Credit Insurance Corporation.

  Notification time: November 21, 2015

  Informed content: After investigation, Comrade Hu Zhengming interfered with the special inspection work of the company by the Central Inspection Team during its stationing in the company, which constituted a violation of the discipline of the Central Inspection Team and the party’s political discipline. In order to enforce the Party’s discipline, according to the relevant provisions of the Regulations on Patrol Work in the Communist Party of China (CPC) and the Regulations on Disciplinary Actions in the Communist Party of China (CPC), Comrade Hu Zhengming was given a serious warning in the Party and transferred from the post of office director of the Party Committee.

  Wu Changshun, former director of Tianjin Public Security Bureau.

  Notification time: August 20, 2015

  The website of the Supervision Department of the Central Commission for Discipline Inspection disclosed in the sixth interpretation of the Regulations on Inspection Work in the Communist Party of China (CPC) published on August 20th, 2015 that during the inspection in Tianjin, the Fifth Inspection Team of the Central Committee fought with Wu Changshun, then vice chairman of the Tianjin Municipal Political Consultative Conference and director of the Public Security Bureau, not only to guard against being monitored and leaked information, but also to find ways to ensure the safety of informants.

  Individual units of China Eastern Airlines Group

  Notification time: October 18, 2015

  When the Ninth Inspection Team of the Central Committee gave feedback to China Eastern Airlines Group on the special inspection, it pointed out that some party organizations did not have a strong sense of the party, and the management of the party was not strict. The implementation of the "two responsibility" was not in place, and individual units had to interfere with the inspection work, and individual leaders violated organizational discipline.

  In January, 2016, when China Eastern Airlines Group Company reported the inspection and rectification, it said that the Party Secretary of a subsidiary that had interfered with the inspection work would be dismissed from his post within the party, and the Party Secretary of the marketing department of the company would be dismissed from his post within the party, subject to administrative demotion. Both of them made written inspections and conducted informed criticism within the group.

  zhengzhou railway bureau

  Notification time: August 20, 2015

  The website of the Supervision Department of the Central Commission for Discipline Inspection disclosed in the sixth interpretation of the Regulations on Inspection Work in the Communist Party of China (CPC) published on August 20, 2015 that when the Eighth Inspection Team of the Central Committee went to Zhengzhou Railway Bureau to understand the situation, it asked its office to provide reception accounts. The unit provided a batch of vouchers to the inspection team, including more than 400 vouchers of more than 2,000 yuan and more than 100 vouchers of more than 3,500 yuan. With such a large amount and so many times, how many people eat each meal and what do they eat? The inspection team requested relevant materials. The unit refused to provide it, saying that it could not be found, the work notebook was destroyed and the menu could not be provided. The inspection team found the party secretary and director and asked them to perform their main responsibilities to investigate this. It turns out that all the documents provided earlier are false. It turned out that the reception department knew that the inspection team was coming. In order to cover up the serious extravagance and waste, it was suggested to handle the accounts and break them into parts. A large account was processed into several small accounts, and the relevant business departments were asked to fabricate the eating experience. According to the investigation, they spent more than 13,000 yuan on a meal, and the cost of drinks alone was more than 9,000 yuan.

  On August 11th, according to the situation and clues discovered by the inspection team, the party group of China Railway Corporation held a video teleconference to report the recent investigation and punishment of 13 mental problems of leading cadres violating the eight central regulations. Among them, Zhang Junbang, former director of Zhengzhou Railway Bureau, was given a serious warning within the party for seriously exceeding the standard of official reception and eating and drinking public funds, and Yang Weijun, secretary of the Party Committee of Zhengzhou Railway Bureau, was given a warning within the party for failing to conscientiously perform the main responsibility of building a clean and honest party style.

  > > relevant regulations:

Regulations of the Communist Party of China (CPC) Municipality on Inspection Work

(August 3, 2015)

  Thirty-seventh patrol area (unit) and its staff in any of the following circumstances, depending on the seriousness of the case, the main person in charge of the leadership of the area (unit) or other relevant responsible personnel, to give criticism and education, organizational treatment or disciplinary action; Suspected of a crime, transferred to judicial organs according to law:

  (a) concealing or deliberately providing false information to the inspection team;

  (2) refusing or failing to provide relevant documents and materials to the inspection team as required;

  (three) instigating or forcing the relevant units or personnel to interfere with or obstruct the inspection work, or falsely accusing or framing others;

  (4) refusing to correct the existing problems without justifiable reasons or failing to make rectification as required;

  (5) Strike, retaliate against or frame up cadres and the masses who reflect the problems;

  (six) other circumstances that interfere with the inspection work.

2023H1: Top10 in revenue ranking of multinational pharmaceutical companies.

With the disclosure of the financial reports of multinational pharmaceutical companies in the second quarter of 2023, we summarized the revenue, net profit and R&D expenses of the top 10 pharmaceutical companies in the first half of 2023.

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Screenshot source: company financial report

In terms of revenue ranking, the Top10 revenues in the first half of 2023 are: Johnson & Johnson, Roche, Pfizer, Merck, Novartis, Abbey, Sanofi, Bristol-Myers Squibb (BMS), AstraZeneca and GlaxoSmithKline (GSK). Among them, Roche, Pfizer, Merck, AbbVie, BMS and GSK experienced negative growth.

In terms of net profit, Roche earned the most, nearly 8.7 billion US dollars. Followed by Pfizer, Johnson & Johnson and Novartis. It is worth noting that Merck lost nearly $3.2 billion in 2023H1.

Judging from the R&D expenses, Merck 2023H1 R&D expenses reached 17.6 billion US dollars, far exceeding those of Johnson, Roche and AstraZeneca.

JNJ

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Screenshot Source: Company official website

On July 20th, Johnson & Johnson released the Q2 financial report for 2023: revenue was $25.53 billion, a year-on-year increase of 6.3%. Among them, the revenue of the pharmaceutical sector was 13.731 billion US dollars, a year-on-year increase of 3.1%; Pharmaceutical business accounts for 54% of the total revenue, which is the highest and fastest growing sector of Johnson & Johnson. So far, Johnson & Johnson’s total revenue in 2023H1 was US$ 50.276 billion, a year-on-year increase of 6%.

As far as products are concerned, the sales of two core products of Johnson & Johnson, Stelara and Darzalex, totaled nearly $10 billion in the first half of the year.

In addition, the sales volume of the BCMA CAR-T product Carvykti (Sida Chiolense) in cooperation with Legendary Bio reached US$ 189 million in the first half of the year, and it is expected to achieve sales volume of about US$ 480 million this year.

Roche

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Screenshot Source: Company official website

On July 27th, Roche released its financial report for the first half of 2023: the Group’s global revenue was 29.779 billion Swiss francs (about 34.2 billion US dollars, calculated at the exchange rate of 1 Swiss franc ≈ 11493 US dollars), down 2% from the previous year. The net profit was 7.563 billion Swiss francs, a year-on-year decrease of 9%; R&D investment was 6.449 billion Swiss francs, up 8% year-on-year.

The tumor field is still Roche’s main position, contributing 9.775 billion Swiss francs, but the growth rate is slowing down.

Among them, Roche’s pharmaceutical sector increased by 8% year-on-year in 2023H1. Among them, the new anti-Vabysmo drug launched in early 2022 once again became the main driving force for growth, with sales of nearly 1 billion Swiss francs.

In addition, the top five drugs in pharmaceutical business in 2023H1 were: Vabysmo, Ocrevus (multiple sclerosis), Hemlibra (hemophilia), Evrysdi (spinal muscular atrophy) and Phesgo (breast cancer), which contributed a total of 7.5 billion Swiss francs in sales, up 42% year-on-year.

Pfizer

18731691479408581

Screenshot Source: Company official website

On August 1st, Pfizer announced its 2023H1 results, with revenue of $31 billion, a year-on-year decrease of 42%. Among them, the revenue in the second quarter was US$ 12.7 billion, down 54% year-on-year. The decline in performance was mainly due to the decline in demand for oral drugs Paxlovid in COVID-19 and Comirnaty in COVID-19.

Although there was a significant year-on-year decline, last year, with the income from vaccines and oral drugs, Pfizer achieved a revenue of 100 billion US dollars, which has been invested in acquisitions and introduction transactions, accumulating stronger comprehensive strength and post-development for Pfizer’s long-term development.

In terms of products, the RSV vaccine just approved by Pfizer is expected to grow into a super blockbuster, and the pneumonia combined vaccine will be listed at 20 prices and iterated at 13 prices. Ibrance, Xtandi related products, and Inlyta contributed the highest sales volume, with 1.25 billion, 310 million and 260 million respectively.

36881691479409331

Screenshot Source: Drug Rong Yun Global Drug R&D Database

Pfizer said that the newly listed and expected listed pipelines will provide higher revenue for the second half of the year, while there are still uncertainties about COVID-19 products, which are expected to be eliminated by the end of the year.

Merck

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Screenshot Source: Company official website

On August 1st, Merck released its second-quarter financial report, with revenue of $15.035 billion, a year-on-year increase of 3%. As a result, the total revenue in the first half of the year was $29.522 billion, down 3% year-on-year. Among them, the income from pharmaceutical business was US$ 26.179 billion, down 3% year-on-year, of which the income from China District was US$ 3.581 billion, up 13.7% year-on-year. R&D expenditure was US$ 17.6 billion, up 227% year-on-year.

In terms of products, the sales of K drug, Keytruda, continued to hit a record high in the first half of the year, reaching US$ 12.065 billion, up 20% year-on-year; Annual sales are expected to reach a new height and reach the top of the "drug king" throne. The sales of HPV vaccine Gardasil in the first half of the year was US$ 4.43 billion, a year-on-year increase of 47%. The total revenue of the two products was $16.495 billion, accounting for 63% of the pharmaceutical business income. However, Humira was hit by bio-similar drugs, and the market shrank rapidly.

In the field of vaccines, Merck’s follow-up heavy products include pneumonia conjugate vaccine. The sales of 15-valent pneumonia conjugate vaccine in the first half of the year was 274 million US dollars, and 21-valent pneumonia vaccine just announced the success of Phase III clinical trial.

References:

1. Financial reports of companies

2. Rong Yun database.

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